Read The Antidote: Inside the World of New Pharma Online

Authors: Barry Werth

Tags: #Biography & Autobiography, #Business & Economics, #Nonfiction, #Retail, #Vertex

The Antidote: Inside the World of New Pharma (74 page)

BOOK: The Antidote: Inside the World of New Pharma
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(
pp. 371
–72) Interview with Keith Johnson. Katie Thomas, and Michael S. Schmidt, “Glaxo Agrees to Pay $3 Billion in Fraud Settlement,”
New York Times
, July 2, 2012.

(
pp. 372
–76) Interviews with Josh Boger and Bo Cumbo. John Carroll, “Vertex Surges as Rival Hep C Contender Plays Catch-Up in Clinic,”
FierceBiotech
, July 31, 2012; Adam Feuerstein, “Bristol’s Hep C Drug Blow Up May Benefit Gilead, Idenix, Vertex Pharma,” TheStreet, August 2, 2012; “Idenix Shares Plunge on Hepatitis C Treatment Fears,” Bloomberg, August 16, 2012; “CDC Recommends One-Time Test for Hepatitis C for All Baby Boomers to Check for Infection,” Associated Press, August 16, 2012; Robert Weisman, “Hepatitis C Testing May Lift Vertex’s Market,”
Boston Globe
, August 18, 2012; Adam Feuerstein, “Vertex Advances One of Two Hep C Drugs,” TheStreet, September 25, 2012; Meg Tirrell, “Vertex Joins Glaxo, J&J in Testing Hepatitis C Combos,”
BloombergBusinessweek
, November 1, 2012; Ryan McBride, “Hep C Pill Race Report 2012,”
FierceBiotech
, November 14, 2012.

(
pp. 376
–79) Interview with Bo Cumbo. Susan Fernando, “Vertex’ Kalydeco Faces UK Price Pushback Though Solid Cystic Fibrosis Data Warrants Funding Settlement,”
Financial Times
, November 29, 2012; Martin Barrow, “Cystic Fibrosis Drug Kalydeco Gets NHS Funding Go-Ahead,”
London Times
, December 20, 2012; Ben Hirschler, “Analysis: Entering the Age of the $1 Million Medicine,”
Chicago Tribune
, January 3, 3013; Matthew Herper, “Inside the Pricing of a $300,000-a-Year Drug,”
Forbes
, January 3, 2013; Ben Hirschler, “Cashing in on Rare Diseases,”
Times Colonist
, January 6, 2012.

(
pp. 379
–81) Interviews with Bo Cumbo, Mark Murcko, and Peter Kolchinsky. Robert Weisman, “Surge in Federal Approvals Buoys Drug Makers,”
Boston Globe
, January 8, 2012; Meg Tirrell, “Vertex Refocuses Drug Development to Specialty Diseases,” Bloomberg, January 9, 2013; Julie M. Donnelly, “Vertex Hepatitis C Drug Revenues Plummet,”
Boston Business Journal
, January 29, 2012; Luke Timmerman, “If You’ve Got a Real Breakthrough, the FDA Wants to Talk,” Xconomy, January 14, 2012.

(
pp. 381
–83) Interview with Keith Johnson. John Carroll, “Vertex Plots a Race Through Phase III for ‘Breakthrough’ Combo CF Therapy,”
FierceBiotech
, February 26, 2013.

AFTERWORD

(
pp. 385
–89) Interviews with Josh Boger, Ken Boger, and Bink Garrison. Boger’s 2039 Annual Report, courtesy of the author.

INDEX

Abbott Laboratories,
317
,
372

HCV and,
333
,
373
,
375
,
377

HIV and,
19
,
24
,
36
,
356
–57

acquired immunodeficiency syndrome (AIDS),
7
,
13
,
31
,
268
,
279

Berlin conference on,
19
–20,
30
,
36
,
76

deaths due to,
20
,
36
,
49
,
242

Vancouver conference on,
36
,
230

Washington retroviral conference and,
25
–26

see also
human immunodeficiency virus

acute coronary syndrome,
93
,
99

Adderall XR,
184

advertising,
36
,
46
,
49
,
195
,
208
,
279

advisory committees (AdComms),
361

Incivek and,
226
–27,
230
–31,
238
,
240
,
243
–44,
255
–58,
264
–65,
268
–76,
292
,
344

Merck and,
226
,
230
,
238
,
244
,
264
–68,
272
–73,
275

mock,
227
,
240
,
243
–44,
255
–58,
265
,
267

Victrelis and,
264
–68,
273
,
275
–76,
299

African-Americans,
49
,
245

HCV and,
203
,
223
,
266
,
348

Agenerase (amprenavir, VX-478):

Boger and,
30
–32,
35
,
51

dimming hopes for,
46
–47

HIV and,
25
–26,
28
–32,
35
–36,
46
–47,
50
–51,
56
,
65
,
77
,
85
,
92
,
97
–98,
102
,
147
,
186
,
225

launch and approval of,
50
–51,
56

Murcko and,
28
–29

patenting of,
30
–32,
35
–36

Agouron Pharmaceuticals:

HCV and,
34
,
37

HIV and,
19
,
46
,
63
,
82

Alam, John,
70
–72,
91
,
106
,
175
,
287

Boger’s relationship with,
71
,
163
,
183

HCV and,
83
,
108
,
121
,
128
–32,
137
–40,
149
,
170
–72,
223
,
232
,
275

portfolio process and,
99
–101

VX-745 and,
71
–72,
75

alanine transaminase (ALT),
318

Albrecht, Janice,
265
–66

Aldrich, Richard,
14
,
17
,
56
,
144
,
149
,
172

Boger’s relationship with,
60
,
69

CF and,
69
,
111

comparisons between Smith and,
86

HCV and,
42
–44,
83

HIV and,
26
,
35
–36,
50

ICE and,
51
–52

slogan competition and,
160

Vertex-Kissei partnership and,
12
–13

Vertex-Novartis partnership and,
57
,
59

Vertex’s reorganization and,
59
–60

Vertex-Wellcome partnership and,
26
–27

Alios Biopharma Inc.,
299
–300,
314
,
347
,
358
,
362
,
372
,
375
,
378

ALS 2200,
372
,
375

Alvarez, Alex,
230

American Association for the Study of Liver Diseases (AASLD),
82
,
121
,
124
,
151
,
209
,
376

American Civil Liberties Union (ACLU),
365
–66

Amgen,
6
,
192
,
208
,
354

amino acids,
16
,
33
–34,
126

amprenavir,
see
Agenerase

anemia,
24
,
172
,
200
,
208
,
221
,
267
,
269
–70,
283
,
347

antibiotics,
3
,
31
–32,
80
,
125
,
152
,
230
,
316
,
326

CF and,
252
,
255
,
305
,
381

and Vertex’s presence in China,
170
,
173

antidepressants,
266
,
316
,
372

anti-infectives,
62
,
80
,
82
,
88
,
106
,
109
,
316

anti-inflammatories,
92
,
216
,
314

ICE and,
47
,
77
,
99

VX-745 and,
71
–72

antivirals,
24
,
32
,
84
,
171
,
182
,
224
,
226
,
276
,
365

HCV and,
39
,
44
,
61
–62,
82
,
128
,
130
–31,
149
,
151
,
193
,
208
,
220
–21,
228
,
238
,
348
–49,
357
,
374
–75

HIV and,
13
,
36
,
63

see also
proteases, protease inhibitors

Apple,
44
–45,
136
,
313
,
375

Arrowsmith
(Lewis),
265

asthma,
4
,
57
,
139
,
245

Astra Merck,
210

atazanavir,
272

Atripla,
147
–48

Aurora Biosciences Corporation,
66
–70,
113
,
117
–18,
144

analysts’ tour of,
343
–44

CF and,
67
–70,
79
–81,
118
,
127
,
180
,
182
,
335
,
343
–44

Olson’s interviews with,
80
–81

pain program and,
126
–27

screening technology of,
66
–68,
78
–81

Vertex’s acquisition of,
66
–69,
73
,
75
,
78
–81,
84
–86,
127
,
385

BOOK: The Antidote: Inside the World of New Pharma
6.74Mb size Format: txt, pdf, ePub
ads

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