Read The Antidote: Inside the World of New Pharma Online
Authors: Barry Werth
Tags: #Biography & Autobiography, #Business & Economics, #Nonfiction, #Retail, #Vertex
(
pp. 371
–72) Interview with Keith Johnson. Katie Thomas, and Michael S. Schmidt, “Glaxo Agrees to Pay $3 Billion in Fraud Settlement,”
New York Times
, July 2, 2012.
(
pp. 372
–76) Interviews with Josh Boger and Bo Cumbo. John Carroll, “Vertex Surges as Rival Hep C Contender Plays Catch-Up in Clinic,”
FierceBiotech
, July 31, 2012; Adam Feuerstein, “Bristol’s Hep C Drug Blow Up May Benefit Gilead, Idenix, Vertex Pharma,” TheStreet, August 2, 2012; “Idenix Shares Plunge on Hepatitis C Treatment Fears,” Bloomberg, August 16, 2012; “CDC Recommends One-Time Test for Hepatitis C for All Baby Boomers to Check for Infection,” Associated Press, August 16, 2012; Robert Weisman, “Hepatitis C Testing May Lift Vertex’s Market,”
Boston Globe
, August 18, 2012; Adam Feuerstein, “Vertex Advances One of Two Hep C Drugs,” TheStreet, September 25, 2012; Meg Tirrell, “Vertex Joins Glaxo, J&J in Testing Hepatitis C Combos,”
BloombergBusinessweek
, November 1, 2012; Ryan McBride, “Hep C Pill Race Report 2012,”
FierceBiotech
, November 14, 2012.
(
pp. 376
–79) Interview with Bo Cumbo. Susan Fernando, “Vertex’ Kalydeco Faces UK Price Pushback Though Solid Cystic Fibrosis Data Warrants Funding Settlement,”
Financial Times
, November 29, 2012; Martin Barrow, “Cystic Fibrosis Drug Kalydeco Gets NHS Funding Go-Ahead,”
London Times
, December 20, 2012; Ben Hirschler, “Analysis: Entering the Age of the $1 Million Medicine,”
Chicago Tribune
, January 3, 3013; Matthew Herper, “Inside the Pricing of a $300,000-a-Year Drug,”
Forbes
, January 3, 2013; Ben Hirschler, “Cashing in on Rare Diseases,”
Times Colonist
, January 6, 2012.
(
pp. 379
–81) Interviews with Bo Cumbo, Mark Murcko, and Peter Kolchinsky. Robert Weisman, “Surge in Federal Approvals Buoys Drug Makers,”
Boston Globe
, January 8, 2012; Meg Tirrell, “Vertex Refocuses Drug Development to Specialty Diseases,” Bloomberg, January 9, 2013; Julie M. Donnelly, “Vertex Hepatitis C Drug Revenues Plummet,”
Boston Business Journal
, January 29, 2012; Luke Timmerman, “If You’ve Got a Real Breakthrough, the FDA Wants to Talk,” Xconomy, January 14, 2012.
(
pp. 381
–83) Interview with Keith Johnson. John Carroll, “Vertex Plots a Race Through Phase III for ‘Breakthrough’ Combo CF Therapy,”
FierceBiotech
, February 26, 2013.
(
pp. 385
–89) Interviews with Josh Boger, Ken Boger, and Bink Garrison. Boger’s 2039 Annual Report, courtesy of the author.
acquired immunodeficiency syndrome (AIDS),
7
,
13
,
31
,
268
,
279
Berlin conference on,
19
–20,
30
,
36
,
76
Vancouver conference on,
36
,
230
Washington retroviral conference and,
25
–26
see also
human immunodeficiency virus
Adderall XR,
184
advertising,
36
,
46
,
49
,
195
,
208
,
279
advisory committees (AdComms),
361
Incivek and,
226
–27,
230
–31,
238
,
240
,
243
–44,
255
–58,
264
–65,
268
–76,
292
,
344
Merck and,
226
,
230
,
238
,
244
,
264
–68,
272
–73,
275
mock,
227
,
240
,
243
–44,
255
–58,
265
,
267
Victrelis and,
264
–68,
273
,
275
–76,
299
Agenerase (amprenavir, VX-478):
dimming hopes for,
46
–47
HIV and,
25
–26,
28
–32,
35
–36,
46
–47,
50
–51,
56
,
65
,
77
,
85
,
92
,
97
–98,
102
,
147
,
186
,
225
launch and approval of,
50
–51,
56
Murcko and,
28
–29
Agouron Pharmaceuticals:
Alam, John,
70
–72,
91
,
106
,
175
,
287
Boger’s relationship with,
71
,
163
,
183
HCV and,
83
,
108
,
121
,
128
–32,
137
–40,
149
,
170
–72,
223
,
232
,
275
portfolio process and,
99
–101
alanine transaminase (ALT),
318
Albrecht, Janice,
265
–66
Aldrich, Richard,
14
,
17
,
56
,
144
,
149
,
172
Boger’s relationship with,
60
,
69
comparisons between Smith and,
86
ICE and,
51
–52
slogan competition and,
160
Vertex-Kissei partnership and,
12
–13
Vertex-Novartis partnership and,
57
,
59
Vertex’s reorganization and,
59
–60
Vertex-Wellcome partnership and,
26
–27
Alios Biopharma Inc.,
299
–300,
314
,
347
,
358
,
362
,
372
,
375
,
378
Alvarez, Alex,
230
American Association for the Study of Liver Diseases (AASLD),
82
,
121
,
124
,
151
,
209
,
376
American Civil Liberties Union (ACLU),
365
–66
amprenavir,
see
Agenerase
anemia,
24
,
172
,
200
,
208
,
221
,
267
,
269
–70,
283
,
347
antibiotics,
3
,
31
–32,
80
,
125
,
152
,
230
,
316
,
326
and Vertex’s presence in China,
170
,
173
anti-infectives,
62
,
80
,
82
,
88
,
106
,
109
,
316
anti-inflammatories,
92
,
216
,
314
VX-745 and,
71
–72
antivirals,
24
,
32
,
84
,
171
,
182
,
224
,
226
,
276
,
365
HCV and,
39
,
44
,
61
–62,
82
,
128
,
130
–31,
149
,
151
,
193
,
208
,
220
–21,
228
,
238
,
348
–49,
357
,
374
–75
see also
proteases, protease inhibitors
Arrowsmith
(Lewis),
265
Astra Merck,
210
atazanavir,
272
Atripla,
147
–48
Aurora Biosciences Corporation,
66
–70,
113
,
117
–18,
144
analysts’ tour of,
343
–44
CF and,
67
–70,
79
–81,
118
,
127
,
180
,
182
,
335
,
343
–44
Olson’s interviews with,
80
–81
pain program and,
126
–27