The Cancer Chronicles (42 page)

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Authors: George Johnson

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EPILOGUE
Joe’s Cancer

1.
said that about 52,000 people:
“Head and Neck Cancers,” National Cancer Institute website. [
http://www.cancer.gov/cancertopics/factsheet/Sites-Types/head-and-neck
]

2.
“A melanoblastoma is such a swine”:
Alexander Solzhenitsyn,
Cancer Ward,
trans. Nicholas Bethell and David Burg (New York: Farrar, Straus and Giroux, 1969), 202.

3.
a concept called field cancerization:
D. P. Slaughter, H. W. Southwick, and W. Smejkal, “Field Cancerization in Oral Stratified Squamous Epithelium: Clinical Implications of Multicentric Origin,”
Cancer
6, no. 5 (September 1953): 963–68. [
http://www.ncbi.nlm.nih.gov/pubmed/13094644
]

4.
“a ticking time bomb”:
Boudewijn J. M. Braakhuis et al., “A Genetic Explanation of Slaughter’s Concept of Field Cancerization Evidence and Clinical Implications,”
Cancer Research
63, no. 8 (April 15, 2003): 1727–30. [
http://cancerres.aacrjournals.org/content/63/8/1727
] For other references on field cancerization see Gabriel D. Dakubo et al., “Clinical Implications and Utility of Field Cancerization,”
Cancer Cell International
7 (2007): 2; [
http://www.ncbi.nlm.nih.gov/pubmed/17362521
] and M. G. van Oijen and P. J. Slootweg, “Oral Field Cancerization: Carcinogen-induced Independent Events or Micrometastatic Deposits?”
Cancer Epidemiology, Biomarkers & Prevention
9, no. 3 (March 2000): 249–56. [
http://www.ncbi.nlm.nih.gov/pubmed/10750662
]

5.
William Crookes, the inventor:
W. Crookes, “The Emanations of Radium,”
Proceedings of the Royal Society of London
71 (January 1, 1902): 405–8. [
http://archive.org/details/philtrans03789193
]

6.
unveiled it at a gala:
Paul W. Frame, “William Crookes and the Turbulent Luminous Sea,” Oak Ridge Associated Universities website. [
http://www.orau.org/ptp/articlesstories/spinstory.htm
] The piece originally appeared in the
Health Physics Society Newsletter
.

7.
spinthariscopes with the same engraving:
In Robert Bud and Deborah Jean Warner, eds.,
Instruments of Science: An Historical Encyclopedia
(New York: Garland, 1998), 572–73, Helge Kragh writes that the Crookes spinthariscope was produced in the summer of 1903 by several different instrument makers.

8.
“a turbulent, luminous sea”:
W. Crookes, “Certain Properties of the Emanations of Radium,”
Chemical News
87, no. 241 (1903).

Index
adenocarcinomas,
2.1
,
3.1
,
8.1
adolescents, cancer in,
3.1
,
12.1
Adriamycin (doxorubicin),
8.1
,
8.2
,
8.3
aflatoxin,
1.1
,
2.1
,
3.1
Africa,
3.1
,
7.1
African Americans,
7.1
,
7.2
,
8.1
alcohol consumption
alcoholism,
2.1
,
7.1
,
11.1
cancer risk from,
1.1
,
2.1
,
7.1
,
7.2
,
7.3
,
7.4
,
10.1
,
10.2
,
10.3
,
epl.1
Allosaurus,
1.1
,
1.2
,
1.3
,
1.4
alpha particles,
11.1
,
11.2
,
11.3
,
epl.1
Alzheimer’s disease,
9.1
,
9.2
Ames, Bruce,
2.1
,
5.1
,
7.1
Ames test,
5.1
,
7.1
angiogenesis,
4.1
,
5.1
,
6.1
,
9.1
,
9.2
,
10.1
,
12.1
animals, animal kingdom
cancers of,
1.1
,
12.1
research conducted on,
1.1
,
4.1
,
5.1
,
6.1
,
7.1
,
9.1
,
10.1
,
10.2
,
12.1
,
13.1
,
epl.1
Apatosaurus
(
Brontosaurus
),
1.1
,
1.2
,
1.3
,
1.4
asbestos,
2.1
,
7.1
,
8.1
Ashworth, Thomas Ramsden,
4.1
,
4.2
,
4.3
Austin, Robert,
13.1
,
13.2
baldness,
6.1
,
8.1
,
11.1
,
12.1
Barosaurus,
1.1
,
1.2
basal cell carcinoma,
6.1
,
12.1
,
12.2
,
epl.1
benzene,
2.1
,
5.1
,
7.1
beta rays,
11.1
,
11.2
biopsy,
2.1
,
6.1
,
12.1
,
epl.1
bladder cancer,
3.1
,
4.1
,
5.1
,
7.1
as metastatic pathway,
4.1
,
4.2
,
5.1
blood sugar,
see
glucose
bone cancer,
1.1
,
3.1
,
3.2
,
3.3
,
11.1
bone marrow,
1.1
,
3.1
,
8.1
,
8.2
,
11.1
bones,
6.1
,
12.1
BRAF
gene,
12.1
,
12.2
brain
development of,
6.1
,
12.1
metastasis to,
4.1
,
4.2
brain cancer, brain tumors,
1.1
,
2.1
,
5.1
,
6.1
,
7.1
,
7.2
,
7.3
,
12.1
breast cancer,
3.1
,
3.2
,
3.3
,
5.1
,
7.1
,
7.2
,
8.1
,
9.1
,
9.2
,
12.1
,
12.2
as common,
2.1
,
3.1
,
3.2
,
12.1
decline in,
7.1
,
7.2
in history,
3.1
,
3.2
risk factors for,
2.1
,
10.1
,
10.2
,
10.3
Brody, Jane,
8.1
,
10.1
Burkitt’s lymphoma,
3.1
,
5.1
,
7.1
CA-125,
2.1
,
13.1
Canada,
1.1
,
11.1
cancer
ambiguities in,
2.1
,
2.2
,
2.3
,
4.1
,
12.1
complex and convoluted nature of,
10.1
,
12.1
detection methods for,
2.1
,
3.1
,
12.1
as disease of genetic information,
5.1
,
9.1
earliest evidence in genus
Homo,
3.1
evolving historical insights on,
4.1
,
10.1
,
12.1
fear of,
11.1
,
12.1
hallmarks of,
9.1
,
9.2
historical vs. current rate of,
3.1
,
7.1
,
10.1
incidence rates of,
7.1
,
9.1
,
13.1
,
13.2
as incurable,
4.1
,
12.1
,
12.2
long term development of,
2.1
,
10.1
metastatic,
see
metastasis
mortality rates from,
7.1
,
9.1
oldest known case of,
1.1
,
1.2
paradoxes of,
3.1
,
5.1
perceived as contagious,
4.1
,
5.1
physiological safeguards against,
1.1
,
1.2
,
4.1
,
5.1
predictions of epidemic of,
7.1
,
7.2
randomness of,
2.1
,
2.2
,
6.1
,
7.1
,
8.1
,
11.1
,
epl.1
,
epl.2
rare types of,
1.1
,
8.1
,
8.2
,
9.1
,
10.1
,
12.1
,
12.2
recurrence of,
2.1
,
7.1
,
9.1
,
10.1
,
12.1
,
12.2
,
epl.1
reducing the odds in,
8.1
,
13.1
,
epl.1
risk factors for,
see
cancer risk factors
selectiveness in incidence of,
1.1
,
1.2
survival rates for,
4.1
,
12.1
,
12.2
,
12.3
,
epl.1
terminology of,
3.1
,
6.1
,
6.2
,
9.1
,
11.1
,
12.1
trivializing of,
12.1
,
12.2
worldwide incidence of,
7.1
,
11.1
cancer clusters,
2.1
,
7.1

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