Wallach's Interpretation of Diagnostic Tests: Pathways to Arriving at a Clinical Diagnosis (396 page)

BOOK: Wallach's Interpretation of Diagnostic Tests: Pathways to Arriving at a Clinical Diagnosis
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   Tricyclic antidepressants: imipramine, amitriptyline
   Phenothiazines: chlorpromazine, trifluoperazine
   Anesthetics: halothane
   Epsilon aminocaproic acid administered in large doses
   Radiographic contrast agents
   Certain foods (onions, garlic, ginger, black tree fungus) and food supplements
   Disease Induced
   Myeloproliferative neoplasms: moderately severe defect.
   Myelodysplastic syndromes usually mild defect.
   Uremia: defect due to accumulation of guanidinosuccinic acid. It is partially corrected by dialysis. Platelet counts are normal.
   Liver disease: normal platelet counts, except in cases with hypersplenism. Dysfunctional platelets may contribute to bleeding risk.
   Dysproteinemias as seen in multiple myeloma and Waldenström macroglobulinemia: normal platelet counts, except in advanced cases, or as the result of chemotherapy.
   DIC affects platelet function mostly due to the effect of fibrin degradation products (FDP) on platelets.

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