Wallach's Interpretation of Diagnostic Tests: Pathways to Arriving at a Clinical Diagnosis (1058 page)

Read Wallach's Interpretation of Diagnostic Tests: Pathways to Arriving at a Clinical Diagnosis Online

Authors: Mary A. Williamson Mt(ascp) Phd,L. Michael Snyder Md

BOOK: Wallach's Interpretation of Diagnostic Tests: Pathways to Arriving at a Clinical Diagnosis
5.02Mb size Format: txt, pdf, ePub

Normal In

   Mumps
   Macroamylasemia
   Lower value in neonates
   Limitations
   Certain drugs such as cholinergics and opiates may elevate serum lipase.
   Renal disease may elevate the serum lipase.
LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A
2
(Lp-PLA
2
)
*
   Definition
   Lipoprotein-associated phospholipase A
2
(Lp-PLA
2
) is a 45-kDa protein enzyme produced by inflammatory cells and activated endothelial cells. It travels in the blood mainly with LDLs. Lp-PLA
2
hydrolyzes oxidized phospholipids in LDLs, resulting in formation of oxidized free fatty acids and lysophosphatidylcholine, which is proatherogenic. Alternate name is plateletactivating factor acetylhydrolase (PAF-AH).
   Use
   Lp-PLA
2
is considered a risk marker rather than a risk factor for cardiac heart disease.
   In conjunction with hsCRP assay can reliably stratify low-, intermediate-, and high-risk populations.
   Increased Lp-PLA
2
with low LDL-C increases risk of heart disease two times.
   Increased Lp-PLA
2
with high CRP increases risk of heart disease three times.

Other books

Ink by Amanda Sun
El equipaje del rey José by Benito Pérez Galdós
But You Did Not Come Back by Marceline Loridan-Ivens
Esther Stories by Peter Orner
Unknown by Shante Harris
Resonance by Erica O'Rourke
A Load of Hooey by Bob Odenkirk