Wallach's Interpretation of Diagnostic Tests: Pathways to Arriving at a Clinical Diagnosis (1058 page)

Read Wallach's Interpretation of Diagnostic Tests: Pathways to Arriving at a Clinical Diagnosis Online

Authors: Mary A. Williamson Mt(ascp) Phd,L. Michael Snyder Md

BOOK: Wallach's Interpretation of Diagnostic Tests: Pathways to Arriving at a Clinical Diagnosis
12.14Mb size Format: txt, pdf, ePub

Normal In

   Mumps
   Macroamylasemia
   Lower value in neonates
   Limitations
   Certain drugs such as cholinergics and opiates may elevate serum lipase.
   Renal disease may elevate the serum lipase.
LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A
2
(Lp-PLA
2
)
*
   Definition
   Lipoprotein-associated phospholipase A
2
(Lp-PLA
2
) is a 45-kDa protein enzyme produced by inflammatory cells and activated endothelial cells. It travels in the blood mainly with LDLs. Lp-PLA
2
hydrolyzes oxidized phospholipids in LDLs, resulting in formation of oxidized free fatty acids and lysophosphatidylcholine, which is proatherogenic. Alternate name is plateletactivating factor acetylhydrolase (PAF-AH).
   Use
   Lp-PLA
2
is considered a risk marker rather than a risk factor for cardiac heart disease.
   In conjunction with hsCRP assay can reliably stratify low-, intermediate-, and high-risk populations.
   Increased Lp-PLA
2
with low LDL-C increases risk of heart disease two times.
   Increased Lp-PLA
2
with high CRP increases risk of heart disease three times.

Other books

Femininity by Susan Brownmiller
Perfect Summer by Graykowski, Katie
Boomtown by Lani Lynn Vale
Down the Yukon by Will Hobbs
The Collector of Names by Mazzini, Miha
Besieged by Rowena Cory Daniells
The Poisoned Island by Lloyd Shepherd
The Fifth Circle by Tricia Drammeh
Prince of Secrets by Paula Marshall