Wallach's Interpretation of Diagnostic Tests: Pathways to Arriving at a Clinical Diagnosis (1311 page)

   Plasma levels of zinc do not necessarily correlate with tissue levels and do not reliably identify individuals with zinc deficiency. Although plasma levels are generally a good index of zinc status in healthy individuals, these levels are depressed during inflammatory disease states.

   Erythrocyte concentrations of zinc may provide a more useful measure of zinc status during acute or chronic inflammation. Several functional indices also can be used to indirectly assess zinc status. Serum superoxide dismutase and erythrocyte alkaline phosphatase activities have been proposed as indirect markers of zinc status, but these tests are not widely available.

   The conditions of anorexia and starvation also result in low zinc levels.

   Hemolyzed specimens cause false elevation of serum zinc levels.

   Specimens should be collected in metal-free specimen containers.

   Auranofin, chlorthalidone, corticotropin, oral contraceptives, and penicillamine increase zinc levels.

   Anticonvulsants, cisplatin, citrates, corticosteroids, estrogens, interferon, and oral contraceptives decrease zinc levels.

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Submitted by Edward Ginns, MD and Marzena M. Galdzicka, PhD.

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Submitted By Liberto Pechet, MD.

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Submitted By Liberto Pechet, MD.

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Submitted By Amanda J. Jenkins, PhD.

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Submitted By Amanda J. Jenkins, PhD.

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Submitted By Liberto Pechet, MD.

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Submitted by Edward Ginns, MD and Marzena M. Galdzicka, PhD.

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Submitted By Amanda J. Jenkins, PhD.

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Submitted By Amanda J. Jenkins, PhD.

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Submitted by Charles R. Kiefer, PhD.

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Submitted By Liberto Pechet, MD.

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Submitted By Amanda J. Jenkins, PhD.

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Submitted By Liberto Pechet, MD.

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Submitted By Liberto Pechet, MD.

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Submitted By Amanda J. Jenkins, PhD.

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Submitted By Amanda J. Jenkins, PhD.

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Submitted By Liberto Pechet, MD.

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Submitted By Liberto Pechet, MD.

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Submitted By Liberto Pechet, MD.

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Submitted By Liberto Pechet, MD.

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Submitted By Amanda J. Jenkins, PhD.

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Submitted by Liberto Pechet, MD.

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Submitted By Liberto Pechet, MD.

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Submitted By Vishesh Chhibber, MD.

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Submitted By Craig S. Smith, MD.

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Submitted By Craig S. Smith, MD.

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Submitted By Craig S. Smith, MD.

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Submitted By Craig S. Smith, MD.

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Submitted by Edward Ginns, MD and Marzena M. Galdzicka, PhD.

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Submitted by Patricia Minehart Miron, PhD.

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Submitted By Liberto Pechet, MD.

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Submitted By Amanda J. Jenkins, PhD.

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Submitted By Liberto Pechet, MD.

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Submitted By Vishesh Chhibber, MD.

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Submitted By Liberto Pechet, MD.

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Submitted By Amanda J. Jenkins, PhD.

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Submitted by Edward Ginns, MD and Marzena M. Galdzicka, PhD.

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Submitted By Liberto Pechet, MD.

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Note: Similar concepts apply to the quantitation of factor IX and its inhibitors.

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Submitted By Liberto Pechet, MD.

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Submitted By Liberto Pechet, MD.

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Submitted By Liberto Pechet, MD.

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Submitted By Liberto Pechet, MD.

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Increased fibrinogen thought to contribute to thrombophilia.

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Submitted By Liberto Pechet, MD.

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Submitted by Hongbo Yu, MD.

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Submitted by Edward Ginns, MD and Marzena M. Galdzicka, PhD.

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May cause neonatal hypoglycemia.

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Submitted By Amanda J. Jenkins, PhD.

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Submitted By Amanda J. Jenkins, PhD.

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Submitted By Liberto Pechet, MD.

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Submitted By Liberto Pechet, MD.

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Submitted By Liberto Pechet, MD.

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Submitted By Liberto Pechet, MD.

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Submitted By Liberto Pechet, MD.

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Submitted by Edward Ginns, MD and Marzena M. Galdzicka, PhD.

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Submitted By Liberto Pechet, MD.

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Submitted By Craig S. Smith, MD.

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Contributed by Neng Yu, MD.

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Submitted By Amanda J. Jenkins, PhD.