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| individuals with autism produced mu suppression only when they performed hand actions themselves Oberman, L. M., Hubbard, E. M., McCleery, J. P., Altshuler, E. L., Ramachandran, V. S., & Pineda, J. A. (2005). EEG evidence for mirror neuron dysfunction in autism spectrum disorders. Cognitive Brain Research, 24 , 190–198.
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| the conclusion that mirror system activity differs in the autistic sample is unwarranted Nieuwenhuis, S., Forstmann, B. U., & Wagenmakers, E. J. (2011). Erroneous analyses of interactions in neuroscience: A problem of significance. Nature Neuroscience, 14 (9), 1105–1107.
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| One fMRI study found that individuals with autism Dapretto, M., Davies, M. S., Pfeifer, J. H., Scott, A. A., Sigman, M., Bookheimer, S. Y., & Iacoboni, M. (2005). Understanding emotions in others: Mirror neuron dysfunction in children with autism spectrum disorders. Nature Neuroscience, 9 (1), 28–30.
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| The other study found that this group produced decreased activity Williams, J. H., Waiter, G. D., Gilchrist, A., Perrett, D. I., Murray, A. D., & Whiten, A. (2006). Neural mechanisms of imitation and mirror neuron functioning in autistic spectrum disorder. Neuropsychologia, 44 (4), 610–621.
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| Multiple studies have shown roughly equal levels of mu suppression Fan, Y. T., Decety, J., Yang, C. Y., Liu, J. L., & Cheng, Y. (2010). Unbroken mirror neurons in autism spectrum disorders. Journal of Child Psychology and Psychiatry, 51 (9), 981–988; Raymaekers, R., Wiersema, J. R., & Roeyers, H. (2009). EEG study of the mirror neuron system in children with high functioning autism. Brain Research, 1304 , 113–121.
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| a number of fMRI studies have shown equivalent or enhanced mirror system Dinstein, I., Thomas, C., Humphreys, K., Minshew, N., Behr-mann, M., & Heeger, D. J. (2010). Normal movement selectivity in autism. Neuron, 66 (3), 461–469; Marsh, L. E., & Hamilton, A. F. D. C. (2011). Dissociation of mirroring and mentalising systems in autism. NeuroImage, 56 (3), 1511–1519; Martineau, J., Andersson, F., Barthélémy, C., Cottier, J. P., & Destrieux, C. (2010). Atypical activation of the mirror neuron system during perception of hand motion in autism. Brain Research, 1320 , 168–175.
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| imitation performance cannot be so easily equated Southgate, V., & Hamilton, A. F. D. C. (2008). Unbroken mirrors: Challenging a theory of autism. Trends in Cognitive Sciences, 12 (6), 225–229.
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| nonautistic individuals take longer to perform the incompatible movement Bird, G., Leighton, J., Press, C., & Heyes, C. (2007). Intact automatic imitation of human and robot actions in autism spectrum disorders. Proceedings of the Royal Society B: Biological Sciences, 274 (1628), 3027–3031.
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| Another group using a different automatic imitation paradigm Spengler, S., Bird, G., & Brass, M. (2010). Hyperimitation of actions is related to reduced understanding of others’ minds in autism spectrum conditions. Biological Psychiatry, 68 (12), 1148–1155.
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| We tend to assume that outsides and insides match Gilbert, D. T., & Malone, P. S. (1995). The correspondence bias. Psychological Bulletin, 117 (1), 21.
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| the intense world hypothesis of autism Markram, H., Rinaldi, T., & Markram, K. (2007). The intense world syndrome: An alternative hypothesis for autism. Frontiers in Neuroscience, 1 (1), 77–96; Markram, K., & Markram, H. (2010). The intense world theory: A unifying theory of the neurobiology of autism. Frontiers in Human Neuroscience, 4 , 1–29.
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| People are loud confusing creatures… . And they expect me to add eye contact? http://nolongerinabox.wordpress.com/2012/09/19/on-eye-contact/ .
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| In humans, the amygdala seems particularly responsive Adolphs, R., Baron-Cohen, S., & Tranel, D. (2002). Impaired recognition of social emotions following amygdala damage. Journal of Cognitive Neuroscience, 14 (8), 1264–1274.
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| And while the amygdala does respond to intense positive and negative cues Small, D. M., Gregory, M. D., Mak, Y. E., Gitelman, D., Mesulam, M. M., & Parrish, T. (2003). Dissociation of neural representation of intensity and affective valuation in human gustation. Neuron, 39 (4), 701.
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| Even subliminally presented fearful faces Morris, J. S., Öhman, A., & Dolan, R. J. (1999). A subcortical pathway to the right amygdala mediating “unseen” fear. Proceedings of the National Academy of Sciences, 96 (4), 1680–1685; Whalen, P. J., Rauch, S. L., Etcoff, N. L., McInerney, S. C., Lee, M. B., & Jenike, M. A. (1998). Masked presentations of emotional facial expressions modulate amygdala activity without explicit knowledge. Journal of Neuroscience, 18 (1), 411–418.
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| The best initial evidence for an amygdala-autism link Baron-Cohen, S., Ring, H. A., Bullmore, E. T., Wheelwright, S., Ashwin, C., & Williams, S. C. (2000). The amygdala theory of autism. Neuroscience & Biobehavioral Reviews, 24 (3), 355–364; Critchley, H. D., Daly, E. M., Bullmore, E. T., Williams, S. C., Van Amelsvoort, T., Robertson, D. M., … , & Murphy, D. G. (2000). The functional neuroanatomy of social behaviour changes in cerebral blood flow when people with autistic disorder process facial expressions. Brain, 123 (11), 2203–2212; Pierce, K., Müller, R. A., Ambrose, J., Allen, G., & Courchesne, E. (2001). Face processing occurs outside the fusiformface area in autism: Evidence from functional MRI. Brain, 124 (10), 2059–2073.
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| When these findings were combined with the fact that amygdala damage in nonhuman primates Bachevalier, J. (1991). An animal model for childhood autism: Memory loss and socioemotional disturbances following neonatal damage to the limbic system in monkeys. Advances in Neuropsychiatry and Psychopharmacology, 1 , 129–140.
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| Children with autism actually have larger amygdalae Amaral, D. G., Schumann, C. M., & Nordahl, C. W. (2008). Neuroanatomy of autism. Trends in Neurosciences, 31 (3), 137–145.
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| This has been seen in children as young as two to four years old Mosconi, M. W., Cody-Hazlett, H., Poe, M. D., Gerig, G., Gimpel-Smith, R., & Piven, J. (2009). Longitudinal study of amygdala volume and joint attention in 2-to 4-year-old children with autism. Archives of General Psychiatry, 66 (5), 509; Schumann, C. M., Hamstra, J., Goodlin-Jones, B. L., Lotspeich, L. J., Kwon, H., Buonocore, M. H., … , & Amaral, D. G. (2004). The amygdala is enlarged in children but not adolescents with autism; the hippocampus is enlarged at all ages. Journal of Neuroscience, 24 (28), 6392–6401.
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| Seeing that Einstein had an abnormally large parietal lobe Witelson, S. F., Kigar, D. L., & Harvey, T. (1999). The exceptional brain of Albert Einstein. Lancet (London, England), 353 (9170), 2149–2153.
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| a sign that they may be overwhelmed by the environment Juranek, J., Filipek, P. A., Berenji, G. R., Modahl, C., Osann, K., & Spence, M. A. (2006). Association between amygdala volume and anxiety level: Magnetic resonance imaging (MRI) study in autistic children. Journal of Child Neurology, 21 (12), 1051–1058.
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| Autistic children also show enhanced threat detection Krysko, K. M., & Rutherford, M. D. (2009). A threat-detection advantage in those with autism spectrum disorders. Brain and Cognition, 69 (3), 472–480; Kleinhans, N., Johnson, L., Richards, T., Mahurin, R., Greenson, J., Dawson, G., & Aylward, E. (2009). Reduced neural habituation in the amygdala and social impairments in autism spectrum disorders. American Journal of Psychiatry, 166 (4), 467–475.
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| increased amygdala volume at age three Munson, J., Dawson, G., Abbott, R., Faja, S., Webb, S. J., Friedman, S. D., … , & Dager, S. R. (2006). Amygdalar volume and behavioral development in autism. Archives of General Psychiatry, 63 (6), 686.
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| the visual pathways that feed potential threat information to the amygdala Samson, F., Mottron, L., Soulières, I., & Zeffiro, T. A. (2011). Enhanced visual functioning in autism: An ALE meta-analysis. Human Brain Mapping, 33 , 1553-1581.
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| Some evidence also suggests that autistic individuals Baron-Cohen, S., Ashwin, E., Ashwin, C., Tavassoli, T., & Chakrabarti, B. (2009). Talent in autism: Hyper-systemizing, hyper-attention to detail and sensory hypersensitivity. Philosophical Transactions of the Royal Society B: Biological Sciences, 364 (1522), 1377–1383; Blakemore, S. J., Tavassoli, T., Calò, S., Thomas, R. M., Catmur, C., Frith, U., & Haggard, P. (2006). Tactile sensitivity in Asperger syndrome. Brain and Cognition, 61 (1), 5–13; Crane, L., Goddard, L., & Pring, L. (2009). Sensory processing in adults with autism spectrum disorders. Autism, 13 (3), 215–228; Khalfa, S., Bruneau, N., Rogé, B., Georgieff, N., Veuillet, E., Adrien, J. L., … , & Collet, L. (2004). Increased perception of loudness in autism. Hearing Research, 198 (1), 87–92; Kern, J. K., Trivedi, M. H., Garver, C. R., Grannemann, B. D., Andrews, A. A., Savla, J. S., … , & Schroeder, J. L. (2006). The pattern of sensory processing abnormalities in autism. Autism, 10 (5), 480–494.
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| When you or I see a face Neumann, D., Spezio, M. L., Piven, J., & Adolphs, R. (2006). Looking you in the mouth: Abnormal gaze in autism resulting from impaired top-down modulation of visual attention. Social Cognitive and Affective Neuroscience, 1 (3), 194–202.
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| Nonautistics spend nearly twice as much time looking at the eyes Pelphrey, K. A., Sasson, N. J., Reznick, J. S., Paul, G., Goldman, B. D., & Piven, J. (2002). Visual scanning of faces in autism. Journal of Autism and Developmental Disorders, 32 (4), 249–261; Neumann, D., Spezio, M. L., Piven, J., & Adolphs, R. (2006). Looking you in the mouth: Abnormal gaze in autism resulting from impaired top-down modulation of visual attention. Social Cognitive and Affective Neuroscience, 1 (3), 194–202.
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| These differences in social gazing (that is, how we look at faces) Dalton, K. M., Nacewicz, B. M., Johnstone, T., Schaefer, H. S., Gernsbacher, M. A., Goldsmith, H. H., … , & Davidson, R. J. (2005). Gaze fixation and the neural circuitry of face processing in autism. Nature Neuroscience, 8 (4), 519–526.
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| A few decades later, J. J. Becher published Physica Subterranea Becher, J. J. (1669). Physica subterranea. Frankfurt.
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| In 1970, Gordon Gallup made a mirror available Gallup, G. G. (1970). Chimpanzees: Self-recognition. Science, 167 (3914), 86–87.
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| Paralleling work linking social interaction and self-awareness in humans Gallup, G. G. (1977). Self-recognition in primates: A comparative approach to the bidirectional properties of consciousness. American Psychologist, 32 (5), 329.
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| Not without some controversy, results like these Plotnik, J. M., de Waal, F. B., & Reiss, D. (2006). Self-recognition in an Asian elephant. Proceedings of the National Academy of Sciences, 103 (45), 17053–17057; Reiss, D., & Marino, L. (2001). Mirror self-recognition in the bottlenose dolphin: A case of cognitive convergence. Proceedings of the National Academy of Sciences, 98 (10), 5937–5942.
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| In addition, the parietal region that responds Lieberman, M. D. (2007). Social cognitive neuroscience: A review of core processes. Annual Review of Psychology, 58 , 259–289.
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| Long before Descartes, the Oracle at Delphi urged all to “know thyself” Baumeister, R. F. (1986). Identity: Cultural Change and the Struggle for Self. New York: Oxford University Press, p. 153.
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| Bill Kelley, Todd Heatherton, and Neil Macrae, prominent social neuroscientists Kelley, W. M., Macrae, C. N., Wyland, C. L., Caglar, S., Inati, S., & Heatherton, T. F. (2002). Finding the self? An event-related fMRI study. Journal of Cognitive Neuroscience, 14 (5), 785–794.
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| The medial prefrontal region that was observed Denny, B. T., Kober, H., Wager, T. D., & Ochsner, K. N. (2012). A meta-analysis of functional neuroimaging studies of self and other judgments reveals a spatial gradient for mentalizing in medial prefrontal cortex. Journal of Cognitive Neuroscience, 24 (8), 1742–1752.
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| the MPFC was observed in 94 percent Lieberman, M. D. (2010). Social cognitive neuroscience. In S. T. Fiske, D. T. Gilbert, & G. Lindzey (Eds). Handbook of Social Psychology , 5th ed. New York: McGraw-Hill, pp. 143–193.
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| only our closer primate relatives Tsujimoto, S., Genovesio, A., & Wise, S. P. (2011). Frontal pole cortex: Encoding ends at the end of the endbrain. Trends in Cognitive Sciences, 15 (4), 169–176; Preuss, T. M., & Goldman-Rakic, P. S. (1991). Myelo- and cytoarchitecture of the granular frontal cortex and surrounding regions in the strepsirhine primate Galago and the anthropoid primate Macaca. Journal of Comparative Neurology, 310 (4), 429–474.
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| Neuroanatomist Katarina Semendeferi examined the size of BA10 Semendeferi, K., Armstrong, E., Schleicher, A., Zilles, K., & Van Hoesen, G. W. (2001). Prefrontal cortex in humans and apes: A comparative study of area 10. American Journal of Physical Anthropology, 114 (3), 224–241.
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| BA10 is less densely populated with neurons Semendeferi, K., Teffer, K., Buxhoeveden, D. P., Park, M. S., Bludau, S., Amunts, K., … , & Buckwalter, J. (2011). Spatial organization of neurons in the frontal pole sets humans apart from great apes. Cerebral Cortex, 21 (7), 1485–1497.
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| each “represents the unique, the very special Hesse, H. (1923). Demian. New York: Boni & Liverright.
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| The generally accepted rule is pink for the boys, and blue for the girls From Earnshaw’s Infants’ Department in June 1918, as quoted from Smithsonian.com: Jeanne Maglaty, “When Did Girls Start Wearing Pink?” April 8, 2011.
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| learning about ourselves in the real world Mead, G. H. (1934). Mind, Self, and Society from the Standpoint of a Social Behaviorist (C. W. Morris, Ed.). Chicago: University of Chicago; Cooley, C. H. (1902). Human Nature and the Social Order. New York: Scribner.
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| We asked young adolescents (that is, thirteen-year-olds) Pfeifer, J. H., Masten, C. L., Borofsky, L. A., Dapretto, M., Fuligni, A. J., & Lieberman, M. D. (2009). Neural correlates of direct and reflected self-appraisals in adolescents and adults: When social perspective-taking informs self-perception. Child Development, 80 (4), 1016–1038.
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| For the few that are profoundly hypnotizable Crasilneck, H. B., McCranie, E. J., & Jenkins, M. T. (1956). Special indications for hypnosis as a method of anesthesia. JAMA: Journal of the American Medical Association, 162 (18), 1606–1608; Kosslyn, S. M., Thompson, W. L., Costantini-Ferrando, M. F., Alpert, N. M., & Spiegel, D. (2000). Hypnotic visual illusion alters color processing in the brain. American Journal of Psychiatry, 157 (8), 1279–1284; Spiegel, H. (1970). A single-treatment method to stop smoking using ancillary self-hypnosis. International Journal of Clinical and Experimental Hypnosis, 18 (4), 235–250; Surman, O. S., Gottlieb, S. K., Hackett, T. P., & Silverberg, E. L. (1973). Hypnosis in the treatment of warts. Archives of General Psychiatry, 28 (3), 439.
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| In our first study, we convinced undergraduates Falk, E. B., Berkman, E. T., Mann, T., Harrison, B., & Lieberman, M. D. (2010). Predicting persuasion-induced behavior change from the brain. Journal of Neuroscience, 30 , 8421–8424.
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| Focus groups don’t work all that well Nisbett, R. E., & Wilson, T. D. (1977). Telling more than we can know: Verbal reports on mental processes. Psychological Review, 84 (3), 231.
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| this time we used antismoking ads Falk, E. B., Berkman, E. T., & Lieberman, M. D. (2011). Neural activity during health messaging predicts reductions in smoking above and beyond self-report. Health Psychology, 30 , 177–185.
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| separate the ads based on the advertising campaign Falk, E. B., Berkman, E. T., & Lieberman, M. D. (2012). From neural responses to population behavior: Neural focus group predicts population level media effects. Psychological Science, 23 , 439–445.
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| “Living for others [is] such a relief Alain de Botton tweet @alaindebotton 3/5/12, 3:00 a.m.
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| “Only a life lived for others is a life worth while” New York Times (1932). Einstein is terse in rule for success. June 20, p. 17.
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| I don’t really remember what it was like before Louis C.K. quote from Interview with Jessica Grose, June 17, 2011, in Slate titled “Questions for Louis C.K.”
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| Steve Jobs warned the new graduates Steve Jobs, 2005, Stanford commencement.
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